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Actual physical dependence occurs when your body develops a tolerance towards the drug, requiring more of it to realize a particular outcome.Zidovudine: The pharmacologic effects of zidovudine might be diminished on account of enhanced non-hepatic or renal clearance of zidovudine.Numerous remedies may help relieve OUD underneath a physician's surve

Actual physical dependence over a prescribed medication would not signify dependancy. Physical dependence will involve the prevalence of the withdrawal syndrome when There is certainly unexpected reduction or cessation in drug use or if an opiate antagonist is administered. Bodily dependence could be detected just after a few days of opioid therapy